Just the right size: cell counting in Dictyostelium.
نویسندگان
چکیده
The regulation of tissue and organism size plays an essential, but poorly understood, role in multicellular development. Genes have been identified that affect body and organ size in a number of animals. Two recently identified genes, smlA and countin, are required for the proper function of a cell-counting mechanism that regulates organism size in the eukaryotic microorganism Dictyostelium discoideum. The discovery of this process now allows the study of size regulation in a simple multicellular system.
منابع مشابه
A cell-counting factor regulating structure size in Dictyostelium.
Developing Dictyostelium cells form large aggregation streams that break up into groups of 0.2 x 10(5) to 1 x 10(5) cells. Each group then becomes a fruiting body. smlA cells oversecrete an unknown factor that causes aggregation streams to break up into groups of approximately 5 x 10(3) cells and thus form very small fruiting bodies. We have purified the counting factor and find that it behaves...
متن کاملMathematically modelling the effects of counting factor in Dictyostelium discoideum.
Size regulation is a crucial feature in many biological systems, with misregulation leading to dysplasia or hyperplasia. The recent discovery of counting factor (CF) in Dictyostelium discoideum will lead to a greater understanding of how the system regulates the size of a group of cells. In this paper we mathematically model the known effects of CF using two different models: a cellular automat...
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The development of Dictyostelium discoideum is a model for tissue size regulation, as these cells form groups of approximately 2 x 10(4) cells. The group size is regulated in part by a negative feedback pathway mediated by a secreted multipolypeptide complex called counting factor (CF). CF signal transduction involves decreasing intracellular CF glucose levels. A component of CF, countin, has t...
متن کاملRobert Insall
Robert Insall was born in London in 1965, into a family of architects, musicians and historians. To their great surprise, he was obviously scientifically inclined from an early age. He did a B.A. at Cambridge University, then stuck around in Cambridge for a Ph.D., where he got interested in Dictyostelium, followed by a postdoc in Johns Hopkins, where he got interested in chemotaxis and cell mov...
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عنوان ژورنال:
- Trends in genetics : TIG
دوره 16 5 شماره
صفحات -
تاریخ انتشار 2000